Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers.Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers.However, a novel therapeutic approach is needed to further improve patient outcome with these Comb
Abstract Background Duplicated genes frequently experience asymmetric rates of sequence evolution.Relaxed selective constraints and positive selection have both been invoked to explain the observation that one paralog within a gene-duplicate pair exhibits an accelerated rate of sequence evolution.In the majority of studies where asymmetric divergen
People were not well prepared Stroller Accessories for the psychological aftermath of the earthquake in Nepal in April 2015.A higher rate of mental disorder was noted in the ensuing months and there was a need to develop psychosocial interventions, especially for those T-Shirts with poor mental health literacy.Acceptable, affordable and accessible
This paper addresses waste collection problems in which urban household and solid waste are brought from waste collection points to waste disposal plants.The collection of waste from the collection points herein is modeled as a multi-depot vehicle routing problem (MDVRP), aiming at minimizing the total transportation distance.In this study, we prop